2019-11-26
Operating principle
A rapid mix granulator is a multi-purpose mixer/processor equally suitable for high speed dispersion of dry powders (including effervescent powders) and their granulation with aqueous or organic solvents. The equipment is designed to achieve rapid mixing and the formation of consistent granules required for the production of high quality pharmaceutical tablets for solid dosage forms of medication. Good mixing and control of granule size leads to fast tableting speeds and high quality products with low rejection rate.
A rapid mixer granulator usually comprises mixing bowl with a bottom entry agitator or impeller for mixing the materials and a side mounted chopper for granulating the mixture. The operating principle is based on agitation of the contents of the bowl at moderate speed and then running the blade of the chopper at high speeds to achieve granulation. Broadly the operating process therefore takes place in 3 steps
Operating procedure
A. Pre-start Up
B. Start Up and operation
C. Shut Down
Cleaning Procedures
1. Cleaning during batch changeover, but with the same product
2. Cleaning during product changeover
3. Cleaning at shutdown (e.g., end of day cleaning), or during batch changeover of same product (of ascending potency)
4. Cleaning at Product Changeover (same product of descending potency) – Preventative Maintenance of Contact Parts
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